Research on Continuous Synthesis of Nanoparticles Using an Inline High-Shear Mixer: Barium Sulfate

作者：Na Tang, Junbo Wu, Junheng Guo, Yingcheng Wang, Haojie Li, Jiangjiexing Wu, Jinli Zhang · 发表于：Industrial & Engineering Chemistry Research · 年份：2025 · DOI：10.1021/acs.iecr.5c00054 · 被引用次数：3 · 研究领域：Microfluidic and Bio-sensing Technologies、Nanopore and Nanochannel Transport Studies、Minerals Flotation and Separation Techniques

Nanoparticle preparation is the foundation of nanotechnology. Owing to its excellent micromixing and disaggregation performance, the high shear mixer (HSM) is a promising tool for nanoparticle preparation. However, limited research has hindered its understanding and application. Therefore, this work systematically investigates for the first time the effects of rotor tip velocity u i, supersaturation, feed flow rate Q A, free ion ratio R f, and rotor–stator configuration on the precipitation of barium sulfate using inline HSM. The results indicate that the nucleation mechanism, micromixing, and shear collectively determine the primary particle mean size d m and agglomerate mean size d 43 of barium sulfate precipitation. Higher R f, more rotor–stator slotting, or an appropriate increase in u i can effectively reduce d m and d 43 . Finally, the correlation equation for d 43 is provided. These results offer valuable insights for the design and application of inline HSM in nanoparticle preparation.