Risk factors associated with Helicobacter pylori infection in the urban population of China: A nationwide, multi-center, cross-sectional study

作者：Liang Wang, Zheng‐Kang Li, Jinxin Lai, Yu‐Ting Si, Jie Chen, Eng Guan Chua, Lingyan Dai, Qiong Dai, Xu-Bo Dai, Deng Zhao-hui, Hong Du, Qi Fang, Cui Feng, Min He, Guoxin Hu, Yandi Hu, Hui Huang, Yanjiang Huang, Fen Li, Junhong Li, Qixin Li, Zhifang Lin, Haitao Liu, Mingbo Liu, Jinhua Luo, MA Jianhong, Bao-Hua Man, Xiao-Jun Ru, Bo-Fu Tang, Jia-Wei Tang, Sisi Tang, Tian Yan, Zeeshan Umar, Handong Wang, Jiliang Wang, Shuchun Wang, Xiaoling Wang, Tao Wu, Dong Xia, Qing-Quan Xie, Rongzhang Xie, Jiancheng Xu, Jing Xu, Yingying Ye, Gailing Yuan, Quan Yuan, Liyan Zhang, Xin-Yu Zhang, Shulei Zhao, Bin Zhou, Xing-Cheng Zhu, Wen-Bi Zou, Barry J. Marshall, Chin Yen Tay, Zhi-Bo Hou, Bing Gu · 发表于：International Journal of Infectious Diseases · 年份：2025 · DOI：10.1016/j.ijid.2025.107890 · 被引用次数：10 · 研究领域：Helicobacter pylori-related gastroenterology studies、Whipple's Disease and Interleukins、Microscopic Colitis

OBJECTIVES: To assess the risk factors associated with Helicobacter pylori infection in the urban Chinese population. METHODS: The study was conducted from March to November 2023, including 12,902 urban participants aged 18-60 years across 52 cities distributed over 26 provinces in China. Risk factors included socioeconomic status, lifestyles, and public understanding. Univariate and multivariate logistic regression analysis was used to calculate corrected odds ratios (ORs) and 95% confidence intervals (CIs). RESULTS: According to multivariate logistic regression, risk factors associated with significantly higher H. pylori infection rates included residency in developing (OR 1.27, 95% CI 1.13-1.43) and undeveloped cities (OR 1.15, 95% CI 1.02-1.29), obesity (OR 1.37, 95% CI 1.05-1.78), alcohol consumption (OR 1.16, 95% CI 1.05-1.29), tea consumption (OR 1.11, 95% CI 1.01-1.21), and soft drink consumption (OR 1.24, 95% CI 1.09-1.40). Conversely, individuals with moderate awareness (OR 0.79, 95% CI 0.71-0.88) and high awareness (OR 0.57, 95% CI 0.48-0.69) of H. pylori had lower infection rates. CONCLUSION: Our findings highlight the importance of promoting a healthy lifestyle and improving the understanding of H. pylori in reducing the infection rate of the bacterial pathogen in the urban Chinese population.