Association of BMI with mortality and health‐related quality of life among 4.4 million adults: Evidence from a nationwide, population‐based, prospective cohort study

作者：Yi Wu, Chunying Lin, Chunqi Wang, Runsi Wang, Bolin Jin, Xiaoyan Zhang, Bowang Chen, Yang Yang, Jianlan Cui, Wei Xu, Lijuan Song, Hao Yang, Wenyan He, Yan Zhang, Xi Li · 发表于：Diabetes Obesity and Metabolism · 年份：2025 · DOI：10.1111/dom.16325 · 被引用次数：2 · 研究领域：Bariatric Surgery and Outcomes、Diabetes, Cardiovascular Risks, and Lipoproteins、Obesity, Physical Activity, Diet

Abstract Aims The body mass index (BMI), as an easy‐to‐calculate measure of body fatness, is closely associated with all‐cause mortality, but few studies with a large enough scale have examined the relationship between BMI and quality of life. A comprehensive and precise insight into a new range is needed. Materials and Methods Based on the ChinaHEART (Health Evaluation And risk Reduction through nationwide Teamwork), a nationwide, population‐based cohort study, 4,485,773 participants living in 20,159 communities or villages were passively followed for death records, through a linkage of data with the National Mortality Surveillance System and Vital Registration. Firstly, we conducted Cox proportional‐hazards regression models to assess the hazard ratios (HRs) of BMI on the risk of all‐cause and cause‐specific mortality. Secondly, we used logistic regression models to examine associations between BMI and health‐related quality of life (HRQL). Fully adjusted models were adjusted for age, sex, annual household income, occupation, education level, marriage, medical insurance, urbanity, tobacco smoking, alcohol consumption and the history of hypertension, diabetes mellitus, dyslipidaemia and cardiovascular disease (CVD). Results Among the 4 485 773 included participants with an average age of 56.4 ± 10.0 years, 59.0% were female. During the follow‐up period, which had a median duration of 5.3 years, a total of 142 004 cases of all‐cause mortality were confirmed. After adjusting f...