Bleaching effectiveness of hydrogen peroxide containing titanium dioxide: A systematic review and meta-analysis

作者：Yiling Cheng, Chen Su, Bing-Jie Zhong, Hao Yu · 发表于：Journal of Dentistry · 年份：2025 · DOI：10.1016/j.jdent.2025.105692 · 被引用次数：4 · 研究领域：Dental Erosion and Treatment、Pigment Synthesis and Properties、Dental materials and restorations

Objectives This systematic review and meta-analysis aimed to evaluate the efficacy of incorporating titanium dioxide (TiO 2 ) into a hydrogen peroxide (HP) gel to increase bleaching effectiveness. Data sources A comprehensive search was conducted in the PubMed, Web of Science, and Scopus databases through February 12, 2024. Study selection The eligibility criteria included studies comparing the bleaching effectiveness of HP alone to HP with incorporated TiO 2 . The risk of bias for in vitro studies was assessed using the RoBDEMAT tool, while in vivo studies were evaluated using the Cochrane Collaboration tool. Meta-analyses were conducted for color difference (ΔE 00 ) and whiteness index for dentistry (WI D ). The mean difference (MD) and 95% confidence interval (CI) for the ΔE 00 and ΔWI D values were calculated using a random-effects model (α=0.05). Results A total of 17 studies were included in this systematic review, and 5 were included in the meta-analysis. Among the 17 eligible studies, 11 were in vitro studies, and 6 were in vivo studies. The commonly used HP concentrations were 6% and 35%, and the concentrations of incorporated TiO 2 ranged from 0.2% to 10%. The meta-analysis demonstrated that incorporating TiO 2 into HP gels resulted in significantly greater ΔE 00 values ( P =0.04; MD=0.50; 95% CI: 0.01 to 0.98) and ΔWI D values ( P =0.003; MD=2.28; 95% CI: 0.75 to 3.80) than did using HP gels alone, with the ΔWI D exceeding the perceptible threshold. Conclusions HP ...