Artificial Bone Materials for Infected Bone Defects: Advances in Antimicrobial Functions

作者：Di Ying, Tianshou Zhang, Manlin Qi, Bing Han, Biao Dong · 发表于：ACS Biomaterials Science & Engineering · 年份：2025 · DOI：10.1021/acsbiomaterials.4c01940 · 被引用次数：27 · 研究领域：Graphene and Nanomaterials Applications、Bone Tissue Engineering Materials、Orthopedic Infections and Treatments

Infected bone defects, caused by bacterial contamination following disease or injury, result in the partial loss or destruction of bone tissue. Traditional bone transplantation and other clinical approaches often fail to address the therapeutic complexities of these conditions effectively. In recent years, advanced biomaterials have attracted significant attention for their potential to enhance treatment outcomes. This review explores the pathogenic mechanisms underlying infected bone defects, including biofilm formation and bacterial internalization into bone cells, which allow bacteria to evade the host immune system. To control bacterial infection and facilitate bone repair, we focus on antibacterial materials for bone regeneration. A detailed introduction is given on intrinsically antibacterial materials (e.g., metal alloys, oxide materials, carbon-based materials, hydroxyapatite, chitosan, and Sericin). The antibacterial functionality of bone repair materials can be enhanced through strategies such as the incorporation of antimicrobial ions, surface modification, and the combined use of multiple materials to treat infected bone defects. Key innovations discussed include biomaterials that release therapeutic agents, functional contact biomaterials, and bioresponsive materials, which collectively enhance antibacterial efficacy. Research on the clinical translation of antimicrobial bone materials has also facilitated their practical application in infection prevention and b...