Characteristics of lipid accumulation induced by high-altitude environment improve the total antioxidant capacity of Ophiocordyceps sinensis

作者：Tao Wang, Chuyu Tang, Mengjun Xiao, Min He, Yuling Li, Xiuzhang Li · 发表于：Food Chemistry · 年份：2025 · DOI：10.1016/j.foodchem.2025.143812 · 被引用次数：8 · 研究领域：Fungal Biology and Applications、Medicinal Plants and Bioactive Compounds、Exercise and Physiological Responses

Ophiocordyceps sinensis is a traditional Chinese herbal medicine and nutritional supplement, which is rich in functional components beneficial to health. The biosynthesis of these components is affected by environment factors, especially lipids. This study analyzed the lipid mass spectrometry characteristics and total antioxidant capacity (TAC) of O. sinensis in 5 different altitude environments and explored the important contributions of environmental factors. The pathway of glycerophospholipid metabolism and biosynthesis of secondary metabolites in O. sinensis was activated by altitude (AM) and mean annual temperature (MAT) at high altitudes. This stimulated the degradation of triglycerides (TG) and the biosynthesis of phosphatidylcholine (PC), and phosphatidylethanolamine (PE), promoted the accumulation of free radical scavenging (FRS) abilities and antioxidant components (AC), and increased its TAC. This study reflects the important role of high altitude environment on lipid metabolism and the formation of bioactive components in O. sinensis and provides a scientific basis for exploring its medicinal value and nutritional value.