Exosome‐Mediated Lectin Pathway and Resistin‐MIF‐AA Metabolism Axis Drive Immune Dysfunction in Immune Thrombocytopenia (Adv. Sci. 10/2025)

作者：Jin Li, Xiaoqian Wang, Yaoyao Chen, Xianlei Sun, Liyan Fu, Qingxuan Xin, Huilin Zhang, Bo Qin, Nannan Sun, Yingmei Li, Yan Xu, Hui Yang, Dawei Huo, Yong Dong, Shuya Wang, Mengyun Zhao, Quande Lin, Fang Wang, Baohong Yue, Yanxia Gao, Yong Jiang, Rongqun Guo · 发表于：Advanced Science · 年份：2025 · DOI：10.1002/advs.202570066 · 被引用次数：1 · 研究领域：Macrophage Migration Inhibitory Factor、Galectins and Cancer Biology

Immune Thrombocytopenia The exosomes from patients with immune thrombocytopenia induce complement system activation through delivery of FCN2 and MBL2, triggering platelet destruction and hyperactivation of immune cells. The hyperactivated immune cells exploit resistin, MIF and arachidonic acid metabolism to enforce aberrant immune responses- akin to insurgents in hot-air balloons igniting rampant fires across a lightly guarded industrial zone, ultimately unleashing toxic chemical leaks. More details can be found in article number 2412378 by Rongqun Guo, Yong Jiang, Yanxia Gao, and co-workers.