Selective C(sp 2 )–P Cross-Coupling of Alkenylsulfonium Salts with P(O)H Compounds: Divergent Synthesis of Alkenylphosphorus Compounds

作者：Jing Xiao, Dequan Xie, Lude Wang, Donghui Lan, Zilong Tang, Li‐Biao Han · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c00318 · 被引用次数：16 · 研究领域：Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods、Radical Photochemical Reactions

Herein, we report a both regioselective and stereoselective method for the formation of C(sp 2 )–P bonds using alkenylsulfonium salts and >P(O)–H compounds. By employing a palladium catalyst or K 2 CO 3, a variety of ( E )-alkenylphosphorus compounds and terminal alkenylphosphorus compounds were successfully synthesized with high selectivity. Notably, trisubstituted ( Z )-alkenylphosphorus compounds were synthesized for the first time under metal-free conditions. This protocol has a wide substrate scope and good functional group compatibility, providing a direct and highly selective approach for the preparation of various alkenylphosphorus compounds.