Microglial circDlg1 modulates neuroinflammation by blocking PDE4B ubiquitination-dependent degradation associated with Alzheimer's disease

作者：Jiyun Shi, Chenghuan Song, Pingao Zhang, Jing Wang, Wan‐Ying Huang, Ting Yu, Zijie Wei, Lufeng Wang, Lan‐Xue Zhao, Rui Zhang, Lina Hou, Yongfang Zhang, Hongzhuan Chen, Hao Wang · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.104709 · 被引用次数：14 · 研究领域：Circular RNAs in diseases、GDF15 and Related Biomarkers、MicroRNA in disease regulation

The novel microglia-upregulated circDlg1 tightly involves in neuroinflammation in APP/PS1 mice via determining the protein fate of PDE4B. Microglial loss of circDlg1 promotes microglial protective response to Aβ deposition and relieves neuroinflammation, thus suggesting a potential therapeutic strategy that specifically targets the microglial response in AD.