Acetylation-regulated DUSP1 deficiency contributes to renal fibrosis progression

作者：Shaobo Wang, Bo Zhang, Yaqin Wang, Qigang Lan, Liangjing Lv, Tangli Xiao, Yan Li, Mengying Yao, Jun Zhang, Cheng Wang, Yinghui Huang, Jinghong Zhao, Jiachuan Xiong · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.108992 · 被引用次数：11 · 研究领域：Medical Imaging and Pathology Studies、Pulmonary Hypertension Research and Treatments、Parathyroid Disorders and Treatments

These results demonstrate that DUSP1 deficiency accelerates renal fibrosis through Smad3 nuclear translocation, modulated by HDAC1-driven acetylation. HDAC1 inhibition or DUSP1 overexpression significantly alleviated renal damage, highlighting DUSP1's therapeutic potential in combating CKD progression.