Hepatic stellate cell-derived microfibrillar-associated protein 2 prevents liver fibrosis by regulating extracellular matrix and inflammation

作者：Wen Zhang, Wenyue Wu, Ning Zhang, Congjun Li, Yameng Sun, Xiaodong Ge, Hui Han, Shuyan Chen, Anjian Xu, Sai Santosh Babu Komakula, Chao Wang, Nithyananthan Subramaniyam, Qi Han, Aiting Yang, Xuzhen Yan, Natalia Nieto, Hong You, Wei Chen · 发表于：Theranostics · 年份：2025 · DOI：10.7150/thno.109771 · 被引用次数：11 · 研究领域：Liver Disease Diagnosis and Treatment、Liver physiology and pathology、Endoplasmic Reticulum Stress and Disease

: This study reveals the compensatory protective effects of HSC-derived MFAP-2 on liver fibrosis and its underlying mechanisms. Enhancing MFAP-2 in HSCs may therefore benefit patients with liver fibrosis.