Intestinal flora was associated with occurrence risk of chronic non-communicable diseases

作者：Guoheng Jiang, Hongyu Li, Linjun Xie, Jing-Yuan Fan, Shiyi Li, Wenqian Yu, Yiting Xu, Menglin He, Yi Jiang, Xuan Bai, Jin Zhou, Xin Wang · 发表于：World Journal of Gastroenterology · 年份：2025 · DOI：10.3748/wjg.v31.i11.103507 · 被引用次数：7 · 研究领域：Gut microbiota and health、Probiotics and Fermented Foods、Gastrointestinal motility and disorders

BACKGROUND The intestinal flora (IF) has been linked to risks of non-communicable diseases, especially various cancers, stroke, and Alzheimer’s disease. However, many uncertainties of these associations during different stages of growth, development, and aging still exist. Therefore, further in-depth explorations are warranted. AIM To explore the associations of the human IF with disease risks during different stages of growth, development, and aging to achieve more accurate and convincing conclusions. METHODS Cohort, cross-sectional, case-control, and Mendelian randomization studies published in the PubMed and Web of Science databases until December 31, 2023 were systematically reviewed to clarify the associations of the IF at the genus level with the risks of various non-communicable diseases, which were grouped in accordance with the 10th revision of the International Classification of Diseases. RESULTS In total, 57 studies were included to quantitatively examine the influence of the IF on the risks of 30 non-communicable diseases during different stages of growth, development, and aging. Population studies and Mendelian randomization studies confirmed positive associations of the abundances of Bifidobacterium and Ruminococcus with multiple sclerosis. CONCLUSION These findings contribute to a deeper understanding of the roles of the IF and provide novel evidence for effective strategies for the prevention and treatment of non-communicable diseases. In the future, it will b...