Global, regional, and national burden of asthma from 1990 to 2021: A systematic analysis of the global burden of disease study 2021

作者：Zhenyu Mao, Xiaoyan Zhu, Pengdou Zheng, Lingling Wang, Fengqin Zhang, Lixiang Chen, Ling Zhou, Wei Liu, Huiguo Liu · 发表于：Chinese Medical Journal - Pulmonary and Critical Care Medicine · 年份：2025 · DOI：10.1016/j.pccm.2025.02.005 · 被引用次数：32 · 研究领域：Asthma and respiratory diseases、Health Promotion and Cardiovascular Prevention、Delphi Technique in Research

Background: Asthma is a prevalent non-communicable disease that affects individuals of all ages and has emerged as a significant global public health concern. This study aims to conduct a comprehensive assessment of the burden of asthma worldwide, as well as at regional and national levels, utilizing the Global Burden of Diseases (GBD) 2021 database for the years 1990 to 2021. Methods: This study utilized the GBD 2021 database to report the prevalent cases and incident cases of asthma, alongside age-standardized prevalence rates (ASPR), age-standardized incidence rate (ASIR), the number of disability-adjusted life years (DALYs), age-standardized DALY rates (ASDR), the number of deaths, and age-standardized mortality rates (ASMR) at global, regional, and national levels for the year 2021. Additionally, it computed the estimated annual percentage change (EAPC) for these asthma burden indicators from 1990 to 2021. This study further analyzed the levels of the above indicators in different gender and age groups, and investigated the association between asthma ASDR/ASMR levels and socio-demographic index (SDI). It also provided an analysis of the contribution of four risk factors to the overall asthma burden. Results: From 1990 to 2021, the global EAPC for asthma ASIR was -1.04 (95 % confidence interval [CI]:-1.18 to -0.89), the EAPC for ASPR was -1.59 (95 % CI:-1.74 to -1.43), the EAPC for ASDR was -1.91 (95 % CI:-1.98 to -1.84), and the EAPC for ASMR was -2.03 (95 % CI:-2.09 to ...