Left Atrial Appendage Occlusion in Solid Organ Transplant Patients

作者：Alden J. Dunham, Madison Noom, Fahad Hawk, Luke Casals, Himara Koelmeyer, Ashton Sequeira, Vivek Mehta, Karthic Chandran, Jeet Mehta, Bibhu D. Mohanty · 发表于：JACC Case Reports · 年份：2025 · DOI：10.1016/j.jaccas.2025.103295 · 研究领域：Atrial Fibrillation Management and Outcomes、Cardiac Arrhythmias and Treatments、Cardiac pacing and defibrillation studies

Percutaneous left atrial appendage occlusion (LAAO) is increasingly used to provide nonpharmacologic stroke prevention in patients with atrial fibrillation, particularly patients at high risk for complications of anticoagulation. Randomized controlled trials establishing LAAO safety and efficacy excluded solid organ transplantation recipients; thus, the role of LAAO in these patients is poorly understood. We present a series of patients with a history of solid organ transplantation who underwent LAAO and include patient-level data on indication, safety, and long-term outcomes. Our cohort demonstrated excellent efficacy and procedural safety with successful implantation in all cases, no major periprocedural complications, and successful discontinuation of systemic anticoagulation.