The Impact of High lncRNA Expression on Clinicopathological Characteristics and Prognosis of Endometrial Cancer Patients: A Meta‐Analysis

作者：Xiaotong Zhao, Ziling Yang, Tianjiao Zheng, Mengyao Zeng, Xiaowen Lin, Huixin Chen, Weiqin Zheng, Sizheng Peng, Shibo Li, Tao Song, Yuhui Sun · 发表于：Cancer Medicine · 年份：2025 · DOI：10.1002/cam4.70755 · 被引用次数：2 · 研究领域：Endometrial and Cervical Cancer Treatments、Cancer-related molecular mechanisms research、Lymphatic System and Diseases

ABSTRACT Backgrounds A growing number of systematic bioinformatics analyses were conducted to investigate the mechanism of interaction between long non‐coding RNA (lncRNA) and endometrial carcinoma (EC) to predict the prognosis. However, there is no evidence‐based evidence that abnormal lncRNA expression is strongly associated with the pathological characteristics and prognosis of EC patients. In this meta‐analysis, we systematically evaluated the relationship between upregulated lncRNA expression levels and clinicopathological features, five‐year survival rate, and progression‐free survival (PFS). Methods A systematic search was performed across seven reputable databases, namely the China National Knowledge Infrastructure, Wanfang, Wipu, PubMed, Web of Science, Cochrane Library, and Embase, encompassing the period from the inception of each database until November 27, 2022. Heterogeneity among the studies was assessed through the application of Cochran's Q and I 2 statistics. All statistical analyses were conducted using Stata 14.0 software. Results This study encompassed 30 clinical studies, involving a total of 2469 EC patients, and examined the expression of 24 lncRNAs, which were upregulated in EC samples. EC patients with higher expression of lncRNAs showed a later FIGO stage (OR = 1.94, 95% CI: 1.29 ~ 2.91), a poorer histological grade (OR = 3.40, 95% CI: 2.51 ~ 4.60), earlier deep myometrial invasion (OR = 2.57, 95% CI: 1.94 ~ 3.41), a higher likelihood of lymphatic v...