Improving Tumor Targeting and Penetration for Nanoparticle‐Mediated Cancer Therapy

作者：Zhangyi Luo, Chien‐Yu Chen, Song Li · 发表于：Small Methods · 年份：2025 · DOI：10.1002/smtd.202401860 · 被引用次数：23 · 研究领域：Nanoparticle-Based Drug Delivery、Nanoplatforms for cancer theranostics、RNA Interference and Gene Delivery

Recent advances in the development of tumor-targeting nanoparticles (NPs) significantly enhance cancer therapies by effectively increasing the therapeutic window of drugs, improving the response of tumor cells, and augmenting anti-tumor immunity. However, the understanding of the tumor-targeting process remains elusive because of the complex in vivo behavior of nanoparticles. Various factors are reported to alter this process; however, systematic studies on tumor-targeting mechanisms remain limited. In this review, an overview of current strategies for improving tumor targeting and their applications in cancer chemotherapy and immunotherapy, with a focus on the advancement of the understanding of various in vivo barriers for effective tumor targeting and penetration is provided.