Palladium-Catalyzed and Photoinduced Site-Selective Alkynylation and Oxidation of the Remote C(sp 3 )–H

作者：Panpan Li, Zhi‐gang Yang, Shao-Qun Cai, Wu Liang, Shi-Cui Fang, Jun-Fei Zhao, Bin Pan, Fei Du · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c00271 · 被引用次数：3 · 研究领域：Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions、Radical Photochemical Reactions

)-H bonds under photoirradiation is described. In this reaction, the Pd catalyst acts as both a photocatalyst to generate the nitrogen radical and a cross-coupling catalyst with a terminal alkyne. Attractive features of this system include good functional group tolerance, scalability, convenient reagents, and an operating system. The utility of this protocol is highlighted by its application for derivatization of several valuable aza-heterocycles such as caspase-3 inhibitor and azepinone derivatives.