Additional Use of Hyaluronic Acid-Based Dissolving Microneedle Patches to Treat Psoriatic Plaques: A Randomized Controlled Trial

作者：Hyun Jeong Ju, Ji Yoon Kim, Dohyeon Jeong, Moon-Su Lee, Gyong Moon Kim, Jung Min Bae, Ji Hae Lee · 发表于：Annals of Dermatology · 年份：2025 · DOI：10.5021/ad.24.024 · 被引用次数：8 · 研究领域：Advancements in Transdermal Drug Delivery、Psoriasis: Treatment and Pathogenesis、Photodynamic Therapy Research Studies

Background: Despite advances in systemic targeted therapies, topical agents remain the primary treatment for localized psoriasis.However, their therapeutic effects are often delayed and unsatisfactory.The dissolving microneedle (DMN) patch, a novel transdermal drug delivery system, enhances the absorption of topical agents through micro-channels.Objective: To evaluate the efficacy of DMN patches in enhancing drug delivery and improving clinical outcomes in psoriatic plaques.Methods: A prospective, randomized, split-body study was conducted to verify the efficacy of additional use of DMN patches after topical agent application in psoriasis treatment.Patients with mild psoriasis were enrolled and 6 paired lesions per patient were randomized into 3 groups: ointment-only, ointment-with-no needle patch, and ointment-with-DMN patch.Lesions were treated with a topical agent (betamethasone and calcipotriol) once daily for 2 weeks.Modified psoriasis area and severity index (mPASI) scores were measured weekly.In vitro and ex vivo experiments were performed to confirm micro-channel formation, microneedle dissolution, and drug penetration enhancement.Results: A total of 132 paired lesions from 22 patients were analyzed.The ointment-with-DMN patch group showed significantly improved mPASI scores (80.4%20.5%;5.421.06)compared to the ointment-with-no needle patch (64.6%33.0%;4.941.68)(p<0.05) and ointment-only groups (55.5%31.4%;5.002.15)(p<0.001).In vitro studies demonstrated 2.1-fold enha...