Cardiometabolic disease among frailty phenotype clusters in adults aging with HIV

作者：Raymond C. F. Jones, Ene M. Enogela, Stephanie A. Ruderman, Mari M. Kitahata, Richard D. Moore, Jeffrey M. Jacobson, Maile Karris, Meredith Greene, Julia Fleming, Sonia Napravnik, Greer Burkholder, Joseph A. Delaney, Heidi M. Crane, Amanda L. Willig, Thomas W. Buford · 发表于：The Journal of Frailty & Aging · 年份：2025 · DOI：10.1016/j.tjfa.2025.100011 · 被引用次数：4 · 研究领域：HIV-related health complications and treatments、Frailty in Older Adults、Cardiovascular Function and Risk Factors

BACKGROUND: Age-related morbidity, including frailty and cardiometabolic disease has become increasingly prevalent among people living with HIV (PWH), and each frailty characteristic may, independently and synergistically, play a role in cardiometabolic disease. OBJECTIVE: To evaluate the prevalence of unique frailty clusters and the prevalence ratios of cardiometabolic diseases within frailty clusters among a large diverse cohort of PWH in clinical care. DESIGN: Cross-sectional analyses within longitudinal clinical cohort. SETTING: The Center for AIDS Research Network of Integrated Clinical Systems (CNICS) from 8 Clinics PARTICIPANTS: 4,856 PWH, mean age 61 years. 16 % frail, 45 % pre-frail, 40 % robust. MEASUREMENTS: The validated, modified Fried Phenotype from patient-reported outcomes and clustering (15 clusters) of the frailty characteristics and cardiometabolic diseases (7 diseases and multimorbidity) within each cluster. RESULTS: Among 4856 PWH (age: 61 ± 6 years), the prevalence of frail, pre-frail, and robust was 16 %, 45 %, and 40 %, respectively. The most prevalent cardiometabolic disease among frail PWH was hypertension (62.6 %), followed by dyslipidemia (58.8 %) and diabetes (31.4 %). Among pre-frail PWH, the most prevalent cardiometabolic diseases were dyslipidemia (65.8 %), hypertension (61.8 %), and obesity (30.5 %). The prevalence of cardiometabolic disease among frailty clusters varied. For example, PWH in the "fatigue + poor mobility" cluster had a greater ...