Illness Uncertainty, Burden, and Capacity Among Caregivers of Children With Chronic Uveitis: A Stress and Coping Theory Perspective

作者：Jiali Huang, Ruru Liu, Xi Huang, Jingyao Dai, Yijie Chen, Xiaoxian Zhang, Yuqin Wang, Yanyan Chen · 发表于：American Journal of Ophthalmology · 年份：2025 · DOI：10.1016/j.ajo.2025.03.008 · 被引用次数：5 · 研究领域：Ocular Diseases and Behçet’s Syndrome、Autoimmune and Inflammatory Disorders Research、Childhood Cancer Survivors' Quality of Life

PURPOSE: The aim was to determine the relationships among illness uncertainty and caregiver burden and capacity in caregivers of children with chronic uveitis and to determine whether caregiver burden plays a mediating role in the relationship between illness uncertainty and caregiver capacity. DESIGN: This was a cross-sectional study. METHODS: The sample included 134 caregivers of children with chronic uveitis. All paper questionnaires were collected at a tertiary-level eye hospital in Wenzhou Province, China. Demographic and clinical characteristics and the Parents' Perception of Uncertainty Scale (PPUS), Zarit Burden Interview (ZBI) and Family Caregiver Task Inventory (FCTI) scores were determined. IBM SPSS 26.0, AMOS 26.0 and GraphPad Prism 9.0.0 were used for figure preparation and statistical analyses. RESULTS: Both the PPUS score (r = 0.725, P < .001) and ZBI score (r = 0.756, P < .001) were positively correlated with the FCTI score, indicating that higher levels of illness uncertainty and caregiver burden was significantly correlated with lower caregiver capacity. Illness uncertainty and caregiver burden (both P < .001) were found to be influencing factors of caregiver capacity. Furthermore, the effect of illness uncertainty on caregiver capacity was partly mediated by caregiver burden. The indirect effect was 0.366 (P = .012; 95% CI: 0.102, 0.879), accounting for 40.13% of the total effect. CONCLUSIONS: Our findings revealed that both illness uncertainty and caregive...