Gastrointestinal traits, common inflammatory disorders, gallstones, and biliary tract cancer: A network Mendelian randomization study

作者：Ye Bai, Min Zhang, Lin Chen, Peiwen Zhou, Zhou Bai, Ruobing Wang, Rixin Li, Junzhuo Si, Shuai Zhou, Yanfang Jiang · 发表于：Journal of Advanced Research · 年份：2025 · DOI：10.1016/j.jare.2025.03.010 · 被引用次数：7 · 研究领域：Genetic Associations and Epidemiology、Liver Diseases and Immunity、Cholangiocarcinoma and Gallbladder Cancer Studies

• Gallstone disease, cholecystitis, gallbladder polyps, primary sclerosing cholangitis, and ulcerative colitis may be directly associated with an increased risk of biliary tract cancer. • Ulcerative colitis has been identified as an independent risk factor for biliary tract cancer, gallstones are frequently associated with cholecystitis, and the presence of gallbladder polyps is a primary etiological factor for biliary tract cancer. • Interleukin-1, a key mediator in ulcerative colitis inflammation, is linked to a higher risk of biliary tract cancer, indicating its potential role in cancer development in those with ulcerative colitis. • Primary biliary cholangitis, viral hepatitis, chronic pancreatitis, gastritis, gastric ulcer, Crohn’s disease, irritable bowel syndrome, peptic ulcer disease, gastro-esophageal reflux disease, and appendicitis do not appear to be correlated with biliary tract cancer incidence. Observational studies have shown that gallstone disease (GSD), cholecystitis, cholangitis, polyp of gallbladder, viral hepatitis, pancreatitis and gastrointestinal (GI) traits such as H. pylori infection, inflammatory bowel disease, and digestive ulcer are associated with the risk of biliary tract cancer (BTC). However, no study has explored their causal associations. To gain a more comprehensive understanding of the causal relationships between GI traits, inflammatory diseases of the digestive system, gallstones, and the development of BTC, further investigation into a ...