A multicenter cohort study of thyroidectomy-related decision regret in patients with low-risk papillary thyroid microcarcinoma

作者：Genpeng Li, Ruicen Li, Jinjing Zhong, Wenjie Chen, Jinhao Shuai, Mei-Zhu Chen, Feng Deng, Tao Wei, Huairong Tang, Zhihui Li, Jianyong Lei · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-57627-7 · 被引用次数：29 · 研究领域：Thyroid Cancer Diagnosis and Treatment、Patient-Provider Communication in Healthcare、Thyroid and Parathyroid Surgery

The level of thyroidectomy-related regret in patients with clinically low-risk papillary thyroid microcarcinoma (PTMC) and the determinants of decision regret are largely unknown. Here, we show that 319 (24.2%) of those who undergo thyroidectomy and 4 (3.4%) who undergo active surveillance (AS) express heightened regret based on validated decision regret scale (DRS) scores in the first online survey (P < 0.001). Multivariable analysis and the second online survey for patients with heightened regret confirm that postoperative lower thyroid cancer-specific quality of life (QoL) (scar and psychology) (75.5%) is the most common factor for heightened regret of thyroidectomy, followed by preoperative understanding of disease [not at all] (15.0%), presentation of complications (3.8%) and other factors (5.7%). These results highlight that more caution should be exercised when low-risk PTMC patients are scheduled for thyroidectomy. Information about the various treatments for clinically low-risk PTMC, the risk of thyroidectomy and postoperative QoL should be fully communicated during initial counseling. Thyroidectomy is frequently the treatment offered to patients with low-risk papillary thyroid microcarcinoma (PTMC). Here, the authors perform a multicentre online survey to a cohort of patients with PTMC showing that heightened regret may not be an experience of a minority of clinically low-risk PTMC patients and is primarily due to lower postoperative quality of life.