Controlled Defluorinative Carboxylation Cascade of Sterically Hindered CF 3 -Alkenes with Formate Salt via Photocatalysis

作者：Runze Zhai, Haiping Yu, Jian‐Ping Ma, Yaxin Sun, Peng Yang · 发表于：Organic Letters · 年份：2025 · DOI：10.1021/acs.orglett.5c00476 · 被引用次数：6 · 研究领域：Fluorine in Organic Chemistry、Inorganic Fluorides and Related Compounds

A controlled cleavage of double C–F bonds in sterically hindered tetrasubstituted CF 3 -alkenes using formate salt has been achieved through a photoinduced electron transfer approach. Diverse γ-branched multifunctionalized gem -difluoroalkenes and α-fluoroacrylic acids are obtained sequentially via hydrodefluorination and C–F bond carboxylation with good-to-high yields. Precisely controlling the quantity of formate salt and the reaction time is crucial for obtaining divergent defluorinative products. Formate serves as the C1 source, hydrogen donor, and reducing agent.