Sedentary Leisure Behaviour, Physical Activity, and Gastroesophageal Reflux Disease: Evidence From a Mendelian Randomization Analysis

作者：Shan Lü, Yahong Zhu, Mingyu Cui, Zheng Guo, Xingang Li, Ying Song · 发表于：Health Science Reports · 年份：2025 · DOI：10.1002/hsr2.70479 · 被引用次数：4 · 研究领域：Gastroesophageal reflux and treatments、Genetic Associations and Epidemiology、Gut microbiota and health

ABSTRACT Background and Aims Gastroesophageal reflux disease (GERD) is common worldwide. Although associations between sedentary behaviour (LSBs), physical activity (PAs), and GERD have been reported, their causal relationships remain unclear. This study uses Mendelian randomization (MR) to examine these associations with GERD. Methods Genetic instruments from the UK Biobank and other consortia were utilized to assess the causal relationship between LSBs, PAs, and GERD. Causal analyses employed inverse variance weighted (IVW), weighted‐median (WM), and MR‐Egger regression. Sensitivity analyses included Cochran's Q test, MR‐Egger intercept test, leave‐one‐out analysis, and funnel plot assessment. Outliers were detected using MR‐PRESSO and Radial MR. A risk factor analysis explored potential causal links. Results Genetically predicted leisure television (TV) watching (OR = 2.29, 95% CI 2.12–2.48; p < 0.001) and self‐reported moderate physical activity (MPAs) (OR = 2.45, 95% CI 1.46–4.13; p < 0.001) were associated with an higher risk of GERD. In contrast, leisure computer use (OR = 0.62, 95% CI 0.53–0.73; p < 0.001) and accelerometer‐measured fractional accelerations > 425 milligravities (OR = 0.68, 95% CI 0.52–0.88; p = 0.003) were associated with a lower risk of GERD. No causal relationship was observed between driving, self‐reported vigorous physical activities (VPAs), and accelerometer‐measured “average acceleration” with GERD. Risk factor analyses suggested tha...