Quasi Fe MIL-53 nanozyme inducing ferroptosis and immunogenic cell death for cancer immunotherapy

作者：Zihui Yan, Yang Bai, Songtao Zhang, Lingyi Kong, Yu Wang, Huilin Sun, Yi Li, Yi Li, Lin Qiu, Ruijie Zhang, Pengju Jiang, Donghui Zhao, Zhongyan Chen, Yafei Li, Yafei Li, Huan Pang, Jianhao Wang · 发表于：Nature Communications · 年份：2025 · DOI：10.1038/s41467-025-57542-x · 被引用次数：72 · 研究领域：Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics、Nanocluster Synthesis and Applications

Nanozymes offer diverse therapeutic potentials for cancer treatment which is dependent on the development of nanomaterials. Quasi-metal-organic framework is a class of metal-organic framework-derived nanomaterials with a transition state from metal-organic frameworks towards metal oxide featuring porous structure and high activity. Herein an iron-based quasi-metal-organic framework nanozyme Q-MIL-53(Fe) is reported via a controlled deligandation strategy, exhibiting enhanced peroxidase-/catalase-mimic activity and glutathione depletion capacity, whose underlying mechanisms are studied via density functional theory calculations. Q-MIL-53(Fe) demonstrates biocompatibility and superior antitumor efficacy compared to pristine MIL-53(Fe). It can activate antitumor immune response by inducing ferroptosis and immunogenic cell death, promoting dendritic cell maturation and T lymphocytes infiltration. Furthermore, a combination of Q-MIL-53(Fe) and programmed cell death protein 1 antibody amplifies cancer immunotherapy. This study validates the antitumor activity of quasi-metal-organic frameworks and its immunotherapy induction potential. It would broaden the application of quasi-metal-organic frameworks and open avenues for developing antitumor nanozymes. Nanozymes offer diverse therapeutic avenues for cancer treatment. In this work, the authors report an iron-based quasi-metal organic framework nanozyme Q-MIL-53(Fe) with enhanced peroxidase and catalase-mimicking activity and glutath...