Hyaluronic acid-based hydrogels modulate neuroinflammation and extracellular matrix remodelling in multiple sclerosis: insights from a primary cortical cell model

作者：Sergio Martín‐Saldaña, Mansoor Al-Waeel, Enrico Bagnoli, Merari Tumin Chevalier, Yazhong Bu, C.H. Lally, Una FitzGerald, Abhay Pandit · 发表于：Materials Horizons · 年份：2025 · DOI：10.1039/d4mh01598c · 被引用次数：11 · 研究领域：Proteoglycans and glycosaminoglycans research、Glycosylation and Glycoproteins Research、Fibroblast Growth Factor Research

, exhibiting an appealing anti-inflammatory response. We also studied the effect of the crosslinked HA hydrogels on hyaluronan metabolism and catabolism markers, showing a significant decrease in HAS2 expression, which could have a critical impact on scar generation in demyelinated axons. Finally, we analyzed the effect of the degradation products of the HA constructs, shedding light on the unsolved debate about the potential dual effect of HA-based materials on the CNS depending on their molecular weight. Altogether, our results contribute to baseline knowledge regarding the use of HA-based materials in the context of CNS inflammatory disorders.