Nanoscale Rhodium(I) Based Metal–Organic Framework Demonstrating Intense NIR-II Luminescence for Bioimaging

作者：Wenxuan Wei, Yijing Du, Xiaomei Kang, Yilin Liu, Yujia Liu, Qian Guo, Qun He, Jun Wang, Shoujun Zhu, Jinyuan Zhou, Weifeng Bu · 发表于：Nano Letters · 年份：2025 · DOI：10.1021/acs.nanolett.5c00539 · 被引用次数：9 · 研究领域：Metal-Organic Frameworks: Synthesis and Applications、Nanoplatforms for cancer theranostics、Advanced Nanomaterials in Catalysis

Although luminescent metal–organic frameworks (MOFs) have been widely reported, rare examples were found to emit in the second near-infrared (NIR-II, 1000–1700 nm) window. In this work, two nanoscale rhodium(I)-based MOFs ( Rh-1@SDS and Rh-1@DSPE-PEG ) have been controllably constructed in the aqueous dispersions of sodium dodecyl sulfate (SDS) and 1,2-distearoyl- sn -glycero-3-phosphoethanolamine- N -methoxy-poly(ethylene glycol) (DSPE-PEG), wherein micelle- and vesicle-like aggregates form, respectively, with high colloidal stability. The vesicular dispersion of Rh-1@DSPE-PEG exhibits intense NIR-II luminescence at 1125 (1245, shoulder) nm. Consequently, this nanoMOF was used as an NIR-II luminescence probe, indicative of high-resolution systemic and local vascular imaging, where the postoperative recovery process of flap transplantation was clearly visualized. Meanwhile, it also demonstrates superior tumor targeting in the NIR-II window. To the best of our knowledge, this research represents the first example of nanoMOFs having intense NIR-II luminescence and excellent imaging capabilities.