The Fire Fighter Cancer Cohort Study: Protocol for a Longitudinal Occupational Cohort Study

作者：Jefferey L. Burgess, Shawn C. Beitel, Miriam M. Calkins, Melissa Furlong, Paola Louzado Feliciano, Jamie Kolar Gabriel, Casey Grant, Jaclyn M. Goodrich, Judith M. Graber, Olivia Healy, James Hollister, J. Margaret Hughes, Sara A. Jahnke, Krystal Kern, Frank A Leeb, Alberto Juan Caban-Martinez, Alexander C. Mayer, Russell Osgood, Cynthia Porter, Sreenivasan Ranganathan, Heather M. Stapleton, Natasha Schaefer Solle, Christine A. Toennis, Derek J. Urwin, Michelle Valenti, John J. Gulotta · 发表于：JMIR Research Protocols · 年份：2025 · DOI：10.2196/70522 · 被引用次数：12 · 研究领域：Occupational Health and Performance、Posttraumatic Stress Disorder Research、Pregnancy-related medical research

BACKGROUND: Firefighters are at an increased risk of cancer and other health conditions compared with the general population. However, the specific exposures and mechanisms contributing to these risks are not fully understood. This information is critical to formulate and test protective interventions. OBJECTIVE: The purpose of the Fire Fighter Cancer Cohort Study (FFCCS) is to conduct community-engaged research with the fire service to advance the evaluation and reduction of firefighter exposures, along with understanding and mitigating effects leading to an increased risk of cancer and other health conditions. This involves establishing a long-term (>30 years) firefighter multicenter prospective cohort study. METHODS: The structure of the FFCCS includes a fire service oversight and planning board to provide guidance and foster communication between researchers and fire organizations; a data coordinating center overseeing survey data collection and data management; an exposure assessment center working with quantitative exposure data to construct a firefighter job exposure matrix; and a biomarker analysis center, including a biorepository. Together, the centers evaluate the association between firefighter exposures and toxic health effects. Firefighter research liaisons are involved in all phases of the research. The FFCCS research design primarily uses a set of core and project-specific survey questions accompanied by a collection of biological samples (blood and urine) for...