Effect of adipose-related parameters on mortality in patients with liver cirrhosis: a meta-analysis

作者：Wen Zhang, Shuyue Tuo, Qiuju Ran, Jia Yuan, Yongle Li, Ying Zhang, Danyan Chang, Chan Li, Shejiao Dai, Jinhai Wang, Xinxing Tantai · 发表于：Annals of Medicine · 年份：2025 · DOI：10.1080/07853890.2025.2473627 · 被引用次数：3 · 研究领域：Nutrition and Health in Aging、Liver Disease Diagnosis and Treatment、Cardiovascular Disease and Adiposity

BACKGROUND: Some adipose-related parameters exhibit distinct prognostic value in patients with cirrhosis. However, the magnitude and direction of the association between individual adipose parameter and mortality in patients with cirrhosis are unclear. AIM: This study aimed to evaluate the association between individual adipose parameter and mortality in patients with cirrhosis using the meta-analysis method. METHODS: The PubMed, Embase, Web of Science, China Biological Medicine, WanFang, and China National Knowledge Infrastructure databases were searched from inception through December 15, 2023, to identify eligible studies. The impact of each adipose parameter on mortality was assessed by the pooled unadjusted or adjusted hazard ratio (HR) with 95% confidence intervals (CIs) using the random effects model. RESULTS: A total of 33 studies involving 9626 patients were included in our analysis, with 11 adipose parameters evaluated. The pooled prevalence of sarcopenic obesity (SO) and myosteatosis in patients with cirrhosis was 15.5% and 34.4%, respectively. In adjusted analysis, each unit increase in subcutaneous adipose tissue index (SATI) (HR: 0.99, 95% CI: 0.98-1.00) or muscle attenuation (MA) (HR: 0.94, 95% CI: 0.90-0.98) and each unit decrease in visceral-to-subcutaneous adipose tissue ratio (VSR) (HR: 1.92, 95% CI: 1.45-2.54) showed an independent association with a decreased risk of mortality. However, concurrent myosteatosis (HR: 1.88, 95% CI: 1.48-2.40) or SO (HR: 2.77...