Association between rheumatoid arthritis and hyperuricemia among adults: a cross-sectional study based on NHANES data

作者：Chanjing Zhao, Qian Xiao, Wen Huang, Yushun Chen, Xuran Yang · 发表于：Clinical Rheumatology · 年份：2025 · DOI：10.1007/s10067-025-07386-z · 被引用次数：7 · 研究领域：Gout, Hyperuricemia, Uric Acid、Rheumatoid Arthritis Research and Therapies、Inflammatory Myopathies and Dermatomyositis

Abstract Objectives This study aimed to explore the relationship between rheumatoid arthritis (RA) and hyperuricemia among adults. Method All the data were from the National Health and Nutrition Examination Survey (NHANES 1997–2018) database. Linear regression, logistic regression, and restricted cubic spline (RCS) analyses were used to investigate the association between RA and hyperuricemia. Subgroup analysis and interaction tests were conducted to assess the influence of various subgroups on their association. Results This study included 41,460 patients, among whom 2603 had RA. The RA group had higher uric acid levels compared with the non-RA group ( P < 0.001). Linear regression showed that RA was significantly related to uric acid levels among several adjusted models (all P < 0.05). Logistic regression analysis also indicated the independent association between RA and hyperuricemia in a positive relationship ( P < 0.05). Subgroup analysis revealed significant association in the subgroups of females, age ≥ 60 years, non-Hispanics, individuals with hypertension and antihypertensive drugs use, and those with BMI ≥ 30 kg/m 2 (all P < 0.05). The interaction test showed that there was no interaction effect between baseline features and RA (all interaction P > 0.05). RCS analysis further found that the course of RA, rather than the age of diagnosis, was related to hyperuricemia ( P < 0.05). Furthermore, we found that the association between RA and hyperuricemi...