The dynamic change of tuberculosis infection prevalence in rural residents: 10-year follow-up of a population-based, multicentre cohort study from China

作者：Xuefang Cao, Lei Gao, Henan Xin, Limei Zhu, Weitao Duan, Boxuan Feng, Wei Lu, Zisen Liu, Yijun He, Lingyu Shen, Juanjuan Huang, Bin Zhang, Dakuan Wang, Jiaoxia Yan, Cheng Chen, Lihui Wang, Wenhua Yin, Guochen Wang, Tonglei Guo, Yuanzhi Di, Zihan Li, Jianguo Liang, Yaqi Zhao, Hongzhi Li, Fei Shen, Jiang Du, Qi Jin · 发表于：The Lancet Regional Health - Western Pacific · 年份：2025 · DOI：10.1016/j.lanwpc.2025.101509 · 被引用次数：3 · 研究领域：Tuberculosis Research and Epidemiology、Diagnosis and treatment of tuberculosis、Healthcare Systems and Reforms

Background: The incidence of tuberculosis (TB) decreased significantly in recent years in China. However, the declining in the burden of tuberculosis infection (TBI) have not been systematically evaluated. The aim of this study was to elucidate the changes of TBI prevalence during the past decade. Methods: Based on a population-based, multicenter cohort study (LATENTTB-NSTM), a 10-year follow-up survey was conducted among registered residents (≥18 years old) at two study sites (Zhongmu and Danyang) using open-cohort design. After excluding active TB, tuberculin skin test (TST) and interferon-γ release assay (IGRA) were used to determine TBI status of each participant. Findings: Overall, 5924 eligible participants who completed the follow-up survey were included in the analysis. Compared to the age- and gender-standardized TBI prevalence determined by IGRA in 2013, the prevalence of TBI was observed to be decreased by 22·24% (from 15·11% to 11·75%) in Danyang site and by 40·86% (from 16·57% to 9·80%) in Zhongmu site in 2023. A consistently declining trend was observed as well for TBI prevalence determined by TST test. The acquisition of TBI in 10 years was assessed by the conversion rate of IGRA result in 4648 participants who participated in both the 2013 and 2023 surveys. The IGRA conversion rate in Danyang site was significantly higher than that in Zhongmu site (4% vs. 2%, p < 0·0001). The reversion rate of IGRA result was assessed as well, and no statistically significant ...