Postoperative Outcomes in Normotensive and Hypertensive Pheochromocytomas: An International Study

作者：Marta Araujo‐Castro, Aura D. Herrera‐Martínez, Yanbo Wang, Zhicheng Wang, Maciej Śledziński, Andrzej Hellmann, Marco Raffaelli, Francesco Pennestrì, Mark Sywak, Alexander Papachristos, Fausto Palazzo, Tae‐Yon Sung, Byung-Chang Kim, Yu‐Mi Lee, Fiona Eatock, Hannah Anderson, Maurizio Iacobone, Albertas Daukša, Özer Makay, Yiğit Türk, Hafize Basut Atalay, Els J.�M. Nieveen van Dijkum, Anton F. Engelsman, Isabelle Holscher, Gabriele Materazzi, Leonardo Rossi, Chiara Becucci, Susannah Shore, Clare Fung, Alison Waghorn, Radu Mihai, Sabapathy P. Balasubramanian, Arslan Pannu, Shuichi Tatarano, David Velázquez‐Fernández, Julie Ann Miller, Hazel Serrao‐Brown, Yufei Chen, Marco Stefano Demarchi, Reza Djafarrian, H Doran, Kelvin Wang, Michael Stechman, Helen Perry, Johnathan Hubbard, Cristina Lamas, Philippa Mercer, Janet L. Macpherson, Supanut Lumbiganon, María Calatayud, Felicia A. Hanzu, Óscar Vidal, C. Mínguez Ojeda, Theodossis S. Papavramidis, Pablo Rodríguez de Vera Gómez, Abdulaziz Aldrees, Tariq Altwjry, Nuria Valdés, Cristina Álvarez‐Escolá, Íñigo García Sanz, Concepción Blanco Carrera, Laura Manjón, Paz de Miguel Novoa, Mónica Recasens, Rogelio García Centeno, Cristina Robles Lázaro, Klaas Van Den Heede, Sam Van Slycke, Theodora Michalopoulou, Sebastian Aspinall, Ross Melvin, Joel Wen Liang Lau, Wei Keat Cheah, Man Hon Tang, Han Boon Oh, John Ayuk, Kevin Verhoeff, R. Sutcliffe, Alessandro Parente · 发表于：The Journal of Clinical Endocrinology & Metabolism · 年份：2025 · DOI：10.1210/clinem/dgaf154 · 被引用次数：6 · 研究领域：Adrenal and Paraganglionic Tumors、Pituitary Gland Disorders and Treatments、Hormonal Regulation and Hypertension

CONTEXT: Postoperative outcomes of patients with normotensive pheochromocytomas are poorly documented. OBJECTIVE: We aimed to evaluate the impact of preoperative hypertension on postoperative outcomes following adrenalectomy for pheochromocytoma. METHODS: An international retrospective study of patients undergoing adrenalectomy for pheochromocytoma in 46 centers between 2012 and 2022 was performed. Hypertensive and normotensive pheochromocytoma were defined respectively by the presence or absence of hypertension history before or at the time of pheochromocytoma diagnosis. To evaluate differences in postoperative outcomes between hypertensive and normotensive patients, propensity score matched (PSM) analysis was performed. RESULTS: Among 2016 patients with pheochromocytoma, 1034 (51.2%) had preoperative hypertension and 982 (49.8%) were normotensive. Hypertensive patients were 4.5 years older (P < .001), had a higher prevalence of type 2 diabetes (P < .001), had a higher median Charlson Comorbidity Index (2.0 vs 1.0; P < .001), and had an American Society of Anesthesiologists score of III to IV more frequently (41% vs 19.9%; P < .001) than normotensive patients. Nonadjusted analysis demonstrated that hypertensive patients had longer operative time (115.0 vs 103.5 minutes; P = .026), higher rate of vasopressors at skin closure (19.7% vs 15.4%; P = .013), more perioperative blood transfusions (7.7% vs 5.0%; P = .016), and an increased complication rate (21.6% vs 17.7%; P = .029)...