Healthy lifestyle habits, educational attainment, and the risk of 45 age-related health and mortality outcomes in the UK: A prospective cohort study

作者：Yu Huang, Shuo Wang, Le Tian, Xueli Zhang, Shunming Liu, Zhuoting Zhu, Wei Wang, Danli Shi, Mingguang He, Xianwen Shang · 发表于：The journal of nutrition health & aging · 年份：2025 · DOI：10.1016/j.jnha.2025.100525 · 被引用次数：8 · 研究领域：Alcohol Consumption and Health Effects、Genetic Associations and Epidemiology、Nutritional Studies and Diet

OBJECTIVES: This study aimed to evaluate to what extent lifestyle habits, contribute to associations between EA and various conditions, and test the variability in risk reduction for specific health conditions linked to a healthy lifestyle across different EA levels. DESIGN, SETTING, PARTICIPANTS, AND MEASUREMENTS: Data were analyzed from 341,632 UK Biobank participants without baseline cardiovascular disease or cancer (2006-2010). A healthy lifestyle score (0-5) was created by assigning one point for each of five habits: a healthy diet, sufficient physical activity, non-current smoking, moderate alcohol consumption, and low-risk sleep duration. Baseline data on self-reported and genotype-predicted EA were collected, with 45 health outcomes assessed until January 2021. Logistic regression models were used to assess the relationship between EA and lifestyle habits, and associations between the healthy lifestyle score and health/mortality outcomes were examined using Cox proportional hazards model. Moderation analysis tested whether EA modified the associations between a healthy lifestyle and health outcomes, while mediation analysis estimated the proportion of the association between EA and health outcomes explained by lifestyle habits. RESULTS: Both self-reported and genotype-predicted EA were associated with a healthy diet, non-current smoking, low-risk sleep duration, and moderate alcohol consumption, but not low-risk physical activity. A healthy lifestyle is inversely link...