Acute Impact of Nonoptimal Ambient Temperatures on Plasma Levels of 3000 Proteins in Chinese Adults

作者：Yi Tong Guo, Mohsen Mazidi, Neil Wright, Pang Yao, Baihan Wang, Yue Niu, Xi Xia, Xia Meng, Cong Liu, Robert Clarke, Hubert Lam, Christiana Kartsonaki, Iona Y. Millwood, Yiping Chen, Ling Yang, Huaidong Du, Canqing Yu, Dianjianyi Sun, Jun Lv, Liming Li, Junshi Chen, Maxim Barnard, Xiaocao Tian, Kin‐Fai Ho, Ka Hung Chan, Antonio Gasparrini, Haidong Kan, Zhengming Chen, the China Kadoorie Biobank Study Group · 发表于：Environmental Science & Technology · 年份：2025 · DOI：10.1021/acs.est.4c13020 · 被引用次数：8 · 研究领域：Climate Change and Health Impacts、Thermoregulation and physiological responses、Thermal Regulation in Medicine

High Resolution Image Download MS PowerPoint Slide Nonoptimal ambient temperatures (i.e., cold and heat) are leading environmental determinants of major diseases worldwide, but the underlying pathological mechanisms are still poorly understood. We used distributed-lag nonlinear models to examine the associations of cold (5 th percentile: −2.1 °C) and heat (95 th percentile: 29.5 °C) with 2923 plasma proteins in 3926 adults from 10 areas across China. Overall, 949 proteins were significantly (5% false discovery rate) associated with ambient temperature, including 387 (216/171 down/upregulated) with cold, 770 (656/114 down/upregulated) with heat, and 208 with both cold and heat. Above the median reference temperature (17.7 °C), the associations were largely linear, while below it, they were nonlinear with attenuation below 5 °C, potentially reflecting mediation by heating. Among the 949 proteins, >80% were also associated with systolic blood pressure and incident ischemic heart disease risk and enriched in relevant pathological pathways (e.g., inflammation, immunity, and platelet aggregation). Our study provided a novel atlas of plasma proteins associated with nonoptimal temperatures in Chinese adults.