Obesity and overweight in R/R DLBCL patients is associated with a better response to treatment of R2-GDP-GOTEL trial. Potential role of NK CD8 + cells and vitamin D

作者：Lourdes Hontecillas‐Prieto, Daniel J. García-Domínguez, Carlos Jiménez‐Cortegana, Esteban Nogales‐Fernández, Natalia Palazón‐Carrión, Alejandro Martı́n, Eduardo Ríos, Josep Gumà, Mariano Provencio, Antonio Rueda‐Domínguez, Luis de la Cruz‐Merino, Víctor Sánchez‐Margalet · 发表于：Cancer & Metabolism · 年份：2025 · DOI：10.1186/s40170-025-00381-7 · 被引用次数：4 · 研究领域：Cancer Risks and Factors、Lymphoma Diagnosis and Treatment、Inflammatory Biomarkers in Disease Prognosis

BACKGROUND: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma worldwide and is characterized by its heterogeneity. Although first-line therapy improves survival outcomes for DLBCL patients, approximately one third will relapse, often with a poor prognosis. Among the factors influencing prognosis and response to treatment in cancer patients, including those with lymphoma, overweight and obesity have emerged as significant considerations. However, the role of excess weight in DLBCL remains controversial, with studies reporting both negative and positive effects on cancer outcomes. In this translational substudy of the R2-GDP-GOTEL trial, we have evaluated the impact of excess weight as a predictor of treatment response and survival in patients with relapsed/refractory (R/R) DLBCL, and examining its relationship with immune cell dynamics. METHODS: Of the 79 patients who received the R2-GDP scheme in the phase II trial, weight and height parameters were obtained in 75 patients before starting treatment. Blood samples were analyzed by flow cytometry. Statistical analyses were performed to determine the prognostic value of overweight and obesity at baseline in R/R DLBCL patients. RESULTS: Our results indicate that overweight (including obese) patients exhibit longer survival compared to patients of ideal weight. This group also demonstrated a reduction of regulatory T cells with supposedly protumor activity and an increase of Natural Killer (NK...