Gut microbiota, immune cell, colorectal cancer association mediators: a Mendelian randomization study

作者：Yuegang Li, Meng Zhuang, Shiwen Mei, Gang Hu, Jinzhu Zhang, Wenlong Qiu, Xishan Wang, Jianqiang Tang · 发表于：BMC Cancer · 年份：2025 · DOI：10.1186/s12885-025-13574-6 · 被引用次数：5 · 研究领域：Gut microbiota and health、Ferroptosis and cancer prognosis、Cancer Immunotherapy and Biomarkers

There have been previously reported associations between the gut microbiota, immune cells, and colorectal cancer; however, the specific mechanisms underlying these relationships remain largely unexplored and require further research. Therefore, in this study, we aimed to unravel the interactions between the gut microbiota, immune cells, and colorectal cancer. The analysis used genome-wide association study (GWAS) data encompassing 207 microbial taxa and 205 functional pathways and data on 731 immune cell phenotypes. Colorectal cancer data on 6 581 cases and 463 421 controls were sourced from the Integrative Epidemiology Unit Open GWAS Project. Univariate inverse-variance weighted Mendelian randomization analysis was used to identify gut microbial taxa associated with colorectal cancer. Mediation analysis was used to identify the mediating role of specific immune cells in the link between gut bacteria and colorectal cancer. Univariate inverse-variance weighted Mendelian randomization analysis revealed that several microbial taxa from the Actinobacteria and Firmicutes phyla were significantly associated with colorectal cancer. Coriobacteriaceae (odds ratio [OR]: 0.84, 95% confidence interval [CI]: 0.72–0.97), Sutterellaceae (OR: 0.88, 95% CI: 0.78–0.99), Eggerthella (OR: 0.91, 95% CI: 0.84–0.99), Coriobacteriales (OR: 0.84, 95% CI: 0.72–0.97), Collinsella aerofaciens (OR: 0.85, 95% CI: 0.74–0.99), and Ruminococcus bromii (OR: 0.91, 95% CI: 0.83–0.99) were negatively associated ...