Metal-Free Nanozyme-Hydrogel Enabled by Conductive Polymer Nanofibers for Multimodal Antibacterial Therapy

作者：Wenya Xu, Ziyi Zhu, Zhen Tan, Ziteng Fan, Shibing Wei, Kaili Yang, Lihui Yuwen, Wen Yang, E. T. Kang, Lianhui Wang · 发表于：Chemistry of Materials · 年份：2025 · DOI：10.1021/acs.chemmater.4c02480 · 被引用次数：8 · 研究领域：Advanced Nanomaterials in Catalysis、Nanoplatforms for cancer theranostics、Electrochemical sensors and biosensors

The nanozyme antibacterial materials have been of great interest due to their broad-spectrum activity and minimal drug resistance. A variety of metal-based nanozymes have been designed as bactericidal agents, whereas their biosafety issues are still serious concerns. Accordingly, the development of metal-free nanozymes and the corresponding hydrogel dressings is of great importance for antibacterial applications. Herein, a classical conductive polymer, polyaniline nanofibers (PANI NF), has been developed as a three-pronged metal-free enzyme-like antibacterial material. They exhibited high oxidase-like and peroxidase-like activities for reactive oxygen species (ROS) production, positively charged surfaces capable of capturing/trapping bacteria to reduce ROS diffusion distance, and unique photothermal ablation effect. By harnessing the intrinsic merits of PANI NF, a PANI/poly(vinyl alcohol) (PANI/PVA) nanocomposite hydrogel, with high stability, soft-tissue adhesion properties, self-healing capability, remoldability, and biocompatibility, has been fabricated as biomedical dressings to promote bacteria-infected wound healing. The studies on antibacterial activities of polyaniline nanofibers shed light on the conductive polymer as promising metal-free enzyme-like antibacterial materials. The prepared PANI/PVA hydrogel provides a stable hydrogel dressing without toxic metal leakage for biomedical applications.