Fronto-Thalamic Structural Connectivity Associated With Schizotypy, a Psychosis Risk Phenotype, in Nonclinical Subjects

作者：Igor Nenadić, Johannes Mosebach, Simon Schmitt, Tina Meller, Frederike Stein, Katharina Brosch, Kai G. Ringwald, Julia‐Katharina Pfarr, Susanne Meinert, Hannah Lemke, Lena Waltemate, Katharina Thiel, Nils Opel, Jonathan Repple, Dominik Grotegerd, Olaf Steinsträter, Jens Sommer, Tim Hahn, Andreas Jansen, Udo Dannlowski, Axel Krug, Tilo Kircher · 发表于：Schizophrenia Bulletin · 年份：2025 · DOI：10.1093/schbul/sbad143 · 被引用次数：5 · 研究领域：Advanced Neuroimaging Techniques and Applications、Schizophrenia research and treatment、Functional Brain Connectivity Studies

BACKGROUND AND HYPOTHESIS: Schizotypy is a risk phenotype for the psychosis spectrum and pilot studies suggest a biological continuum underlying this phenotype across health and disease. It is unclear whether this biological continuum might include brain structural associations in networks altered in schizophrenia spectrum disorders, such as the fronto-thalamo-striatal system or nodes of the default mode network, such as the precuneus. STUDY DESIGN: In this study, we analyze a large multi-center cohort of 673 nonclinical subjects phenotyped for schizotypal traits (using the Schizotypal Personality Questionnaire-Brief version) using tract-based spatial statistics of diffusion tensor imaging data, as well as voxel-based morphometry (VBM) analysis of regional brain volumes and gyrification analysis of early neurodevelopmental markers of cortical folding on T1-weighted MRI. STUDY RESULTS: We identify significant (P < .05 family-wise error corrected) associations of schizotypy with major fiber tract fractional anisotropy: positive (cognitive-perceptual) schizotypy correlated negatively with the left anterior thalamic radiation (a principal thalamo-frontal projection), left uncinate fasciculus and cingulum, while negative (interpersonal) schizotypy correlated positively with left anterior thalamic radiation, cingulum, and the anterior corpus callosum, and disorganized schizotypy correlated negatively with right cingulum, and superior and inferior longitudinal fasciculi. VBM analyse...