Photo‐Responsive H 2 S Composite System Regulates the Nerve Regeneration Microenvironment Through Multiple Pathways

作者：Yuanfang Huo, Xinyi Tan, Xianzhen Dong, Xinyue Liang, Kun Liu, Hao Zhang, Zhiqiang Li, Junwei Yang, Zixuan Pang, Yawei Yao, Aixi Yu, Honglian Dai · 发表于：Advanced Materials · 年份：2025 · DOI：10.1002/adma.202413992 · 被引用次数：28 · 研究领域：Sulfur Compounds in Biology、Nanoplatforms for cancer theranostics、Obstructive Sleep Apnea Research

Abstract After injury, the imbalance of the regeneration microenvironment caused by inflammation, oxidative stress, insufficient neurovascularization, and inadequate energy supply affects nerve regeneration. Drug‐delivery nerve conduits play a role in repairing the regenerative microenvironment. However, traditional drugs often fail to cross the blood‐nerve barrier and lack multifunctionality, limiting the effectiveness of conduit therapy. Therefore, it is necessary to construct a multifunctional conduit that regulate the regeneration microenvironment timely and effectively. Herein, a photo‐responsive hydrogen sulfide (H 2 S) composite nerve conduit, artificially controlled H 2 S release, is developed. A new structure of zinc‐citric acid organic metal framework (Zn‐CA MOFs) is utilized to improve its drug loading rate, achieving the joint regulation of the nerve regeneration microenvironment by H 2 S and Zn 2+ . In addition, RGD modification of polyester amide (P(CL‐MMD‐MAC)‐RGD)) combined with aligned structure is used to improve the performance of the conduit. Relevant results demonstrate that H 2 S and Zn 2+ can regulate inflammatory response and oxidative stress and promote mitochondrial function recovery and angiogenesis. Furthermore, the aligned structure can promote cell adhesion and guide cell directed migration. Overall, this study provides a method of combining gas neurotransmitters with ions to improve the nerve regeneration microenvironment, accelerate nerve regen...