Berberine and its derivatives: mechanisms of action in myocardial vascular endothelial injury - a review

作者：Wenhui Zhang, Siyi Guo, Jinjin Dou, X. B. Zhang, Fan Shi, Chun Zhang, Huxiao Zhang, Xiaodong Lan, Yi Su · 发表于：Frontiers in Pharmacology · 年份：2025 · DOI：10.3389/fphar.2025.1543697 · 被引用次数：5 · 研究领域：Berberine and alkaloids research、Alkaloids: synthesis and pharmacology、Synthesis and Biological Activity

Myocardial vascular endothelial injury serves as a crucial inducer of cardiovascular diseases. Mechanisms such as endoplasmic reticulum stress, apoptosis, inflammation, oxidative stress, autophagy, platelet dysfunction, and gut microbiota imbalance are intimately linked to this condition. Berberine and its derivatives have demonstrated potential in modulating these mechanisms. This article reviews the pathogenesis of endothelial injury in myocardial vessels, the pharmacological effects of berberine and its derivatives, particularly their interactions with targets implicated in vascular endothelial injury. Furthermore, it discusses clinical applications, methods to enhance bioavailability, and toxicity concerns, aiming to lay a foundation for the development of BBR as a therapeutic agent for cardiovascular diseases.