Talarombrevisone A, an β -aminopropionate with two polyketide units, isolated from an endophytic fungus Talaromyces brevis

作者：Yun-He Tuo, Zhong‐Duo Yang, Jianguo Chen, Cheng‐Yuan Xu, Lin-bo Liu, Tiankun Zhao, Yue Li, Li-Bin Xia, Shuai Yu, Ai-Hong Zhao, Shuo Li · 发表于：Natural Product Research · 年份：2025 · DOI：10.1080/14786419.2025.2471845 · 被引用次数：2 · 研究领域：Microbial Natural Products and Biosynthesis、Fungal Biology and Applications、Enzyme Catalysis and Immobilization

Talarombrevisone A (1), Which is a β-aminopropionate compound containing two polyketide units, and two known compounds Ethyl linoleate (2) and Talaromycin A (3) were isolated from Talaromyces brevis, an endophytic fungus of Cupressus chengiana. Structure of 1 was elucidated by infra-red, mass spectrometry, one-dimensional and two-dimensional nuclear magnetic resonance (NMR) spectra. The inhibitory activity on phosphodiesterase 1 of the three compounds was investigated. Among them, 3 showed moderate activity with inhibitory rate of 58.35% at 271.6 μM.