The nomogram model predicts relapse risk in myelin oligodendrocyte glycoprotein antibody-associated disease: a single-center study

作者：Jiafei Cheng, Zhuoran Wang, J. Wang, Xiaomin Pang, JianLi Wang, Meini Zhang, Junhong Guo, Huaxing Meng · 发表于：Frontiers in Immunology · 年份：2025 · DOI：10.3389/fimmu.2025.1527057 · 被引用次数：7 · 研究领域：Multiple Sclerosis Research Studies、Peripheral Neuropathies and Disorders、Systemic Lupus Erythematosus Research

Background Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune disorder of the central nervous system, characterized by seropositive MOG antibodies. MOGAD can present with a monophasic or relapsing course, where repeated relapses may lead to a worse prognosis and increased disability. Currently, little is known about the risk factors for predicting MOGAD relapse in a short period, and few established prediction models exist, posing a challenge to timely and personalized clinical diagnosis and treatment. Methods From April 2018 to December 2023, we enrolled 88 patients diagnosed with MOGAD at the First Hospital of Shanxi Medical University and collected basic clinical data. The data were randomly divided into a training cohort (80%) and a validation cohort (20%). Univariate logistic regression, least absolute shrinkage and selection operator (LASSO) regression and multivariate logistic regression were used to identify independent risk factors for 1-year relapse. A prediction model was constructed, and a nomogram was developed. The receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) were used to evaluate and internally validate model performance. Results Among 88 MOGAD patients, 29 relapsed within 1 year of onset (33%). A total of 4 independent risk factors for predicting relapse were identified: female sex ( P =0.040), cortical encephalitis phenotype ( P =0.032), serum MOG antibody titer ≥1:32...