New Types of Post-Translational Modification of Proteins in Cardiovascular Diseases

作者：Juntao Fang, Shaoyu Wu, Hengli Zhao, Chuanmeng Zhou, Ling Xue, Zhiyong Lei, Hui Li, Zhi‐Xin Shan · 发表于：Journal of Cardiovascular Translational Research · 年份：2025 · DOI：10.1007/s12265-025-10600-7 · 被引用次数：10 · 研究领域：Pancreatic function and diabetes、Enzyme Catalysis and Immobilization、Microbial Metabolic Engineering and Bioproduction

Post-translational modifications (PTMs), which are covalent alterations of proteins after their synthesis, are critical for their proper function and the maintenance of cellular physiology. The significance of PTMs in the context of cardiovascular diseases (CVDs) has been increasingly recognized due to their potential to influence protein stability, activity, and localization, thereby affecting the progression of CVDs. The identification and understanding of PTMs in CVDs at the molecular level are vital for the discovery of new biomarkers and new targets for clinical interventions. This article provides a comprehensive overview of the role and mechanisms of new types of PTMs, such as acetylation, crotonylation, succinylation, S-nitrosylation, malonylation, S-palmitonylation, β-hydroxybutyrylation and lactylation, in CVDs, highlighting their importance in advancing diagnostic and therapeutic approaches for CVDs.