FOXA2 loss results in an increase of endometriosis development and LIF reveals a therapeutic effect for endometriosis

作者：Md Saidur Rahman, Tae Hoon Kim, Breton F. Barrier, Thomas E. Spencer, Andrew M. Kelleher, Jae‐Wook Jeong · 发表于：The FASEB Journal · 年份：2025 · DOI：10.1096/fj.202403182r · 被引用次数：6 · 研究领域：Endometriosis Research and Treatment、Reproductive System and Pregnancy、Uterine Myomas and Treatments

Abstract Endometriosis, characterized by the growth of uterine‐like tissue outside the uterus, causes chronic pain and infertility. Current diagnostic and therapeutic strategies have notable limitations, including delayed diagnosis and adverse effects. The transcription factor forkhead box A2 (FOXA2), which is exclusively expressed in the uterine glandular epithelium, regulates key genes involved in endometrial proliferation, differentiation, fertility, and hormone response. While FOXA2 expression is reduced in the endometrial tissue of women with endometriosis, its pathophysiological role in the disease is not well understood. In this study, we report that endometriosis significantly reduced FOXA2 expression in the eutopic endometrium of mice with endometriosis compared to sham controls, accompanied by decreased expression of its downstream gene, CXCL15. To evaluate the effect of FOXA2 loss in endometriosis, we surgically induced endometriosis by transplanting control Rosa26 mTmG/+ or Pgr cre/+ Foxa2 f/f Rosa26 mTmG/+ ( Foxa2 d/d Rosa26 mTmG/+ ) endometrial tissue into the peritoneal cavity of mice. The number and weight of ectopic lesions were significantly increased in the mice with Foxa2 d/d Rosa26 mTmG/+ ectopic lesions compared to controls. Furthermore, progesterone receptor expression was significantly reduced in the endometrial epithelium from mice with Foxa2 d/d Rosa26 mTmG/+ ectopic lesions compared to mice with control ectopic lesions. Importantly, treatment with l...