Epidemiological profile and antimicrobial resistance trends of Staphylococcus aureus in Chinese pediatric intensive care units from 2016 to 2022: a multi-center retrospective study

作者：Xiaolei Zhang, Jing Liu, Pan Fu, Yixue Wang, Panpan Fan, Jin‐Lan Zhou, Xiang Xia, Huili Shen, Tingyan Liu, Yingying Zhang, Ting Zhu, Caiyan Zhang, Chuanqing Wang, Guoping Lü, Gangfeng Yan, the China paediatric Intensive care Unit Pathogen Surveillance Network (CHIPS) Study Group, Hong Ren, Jinyan Li, Yucai Zhang, Yiping Zhou, Cheng-mei Zhang, Zhenjie Chen, Mingming Zhou, Zhijun Bai, Sai-hu Hang, Li-li Hang, H Y Chen, Yao Zheng, Qun-ying Chen, Peng-wei Zhu, Yong Li, Yan Xu, Bizhen Zhu, Hui-xuan Shi, Shao-xian Hong, Yukun Huang, Meilian Huang, Dan-qun Jing, Wen-jia Tong, Chengyu Zhang, Weiguo Yang, Wei-ke Mang, Qing H. Meng, Yi‐Bing Cheng, Qun-qun Zhang, Kaijie Gao, Huiming Xu, Yuxia Li, Hang-hai Ding, Xiulan Lu, Jiaotian Huang, Jianlong Liu, Yourong Zhu, Yuanyuan Chen, Shu-fang Xiao, Juan He, Jiang Li, Jianli Chen, Yi‐Ling Lin, Jia Lei · 发表于：BMC Infectious Diseases · 年份：2025 · DOI：10.1186/s12879-025-10704-0 · 被引用次数：7 · 研究领域：Antimicrobial Resistance in Staphylococcus、Neonatal and Maternal Infections、Antibiotic Use and Resistance

OBJECTIVE: This study aimed to analyze the profiles and evolution of Staphylococcus aureus in the pediatric intensive care units (PICUs) of 17 hospitals in China from 2016 to 2022. METHODS: Susceptibility testing was performed to bacterial strains with a uniform monitoring protocol, which was provided by the US Clinical and Laboratory Standards Institute (CLSI) and used by the China Antimicrobial Surveillance Network (CHINET). The results were interpreted in accordance with the performance standards for antimicrobial susceptibility testing issued by the US Clinical and Laboratory Standards Institute. RESULTS: Twenty-six thousand six hundred thirteen bacterial strains were isolated from 17 PICUs in China from 2016 to 2022, 3,147 of which were Staphylococcus aureus, ranking second among etiological agents of infections from PICUs. In 2022, Staphylococcus aureus had the highest detection rate, being 36.19%. And in 2021, MRSA had the highest detection rate, being 10.35% in Staphylococcus aureus. There were statistically significant differences in the annual detection rate of gram-positive bacteria, Staphylococcus aureus and MRSA between the years from 2016 to 2022 (P < 0.05). More males were found with Staphylococcus aureus or methicillin-resistant Staphylococcus aureus, but there were no statistical differences in gender distribution between any two years (P < 0.05). The top 3 highest detection rate of Staphylococcus aureus in age groups were infants (1244, 39.7%), toddlers (741...