Association of malnutrition risk evaluated by the geriatric nutritional risk index with post-stroke myocardial injury among older patients with first‑ever ischemic stroke

作者：Mu Niu, Faqiang Zhang, Long Wang, Hao Yang, Lina Zhu, Supei Song · 发表于：BMC Geriatrics · 年份：2025 · DOI：10.1186/s12877-025-05796-x · 被引用次数：6 · 研究领域：Nutrition and Health in Aging、Frailty in Older Adults、Acute Ischemic Stroke Management

BACKGROUND: Post-stroke myocardial injury is a potentially preventable complication after acute ischemic stroke. Therefore, identifying modifiable variables, such as nutritional status, is crucial for reducing the risk of post-stroke myocardial injury. This study aimed to investigate the association between malnutrition risk on admission, as evaluated by the Geriatric Nutritional Risk Index (GNRI), and post-stroke myocardial injury in elderly patients with first‑ever ischemic stroke. METHODS: We conducted this study using the GNRI score to evaluate the nutritional status of older patients with first‑ever ischemic stroke. The primary outcome of interest was post-stroke myocardial injury. Restricted cubic spline (RCS) was executed to assess the dose-effect relationship between the GNRI score and post-stroke myocardial injury. The correlation of malnutrition risk identified by GNRI score for post-stroke myocardial injury was examined using multivariate logistic regression analysis. To balance the potential confounders and verify the robustness of the results, propensity score matching (PSM) was further conducted. RESULTS: Based on the GNRI score, 30.8% of patients were at moderate to severe risk of malnutrition. The overall incidence of post-stroke myocardial injury was 33.2%. The adjusted RCS analysis revealed a negative dose-response relationship between the GNRI score and post-stroke myocardial injury (P for non-linearity = 0.536). After adjusting for confounders, moderate to...