Global Prevalence of Helicobacter pylori Infection‐Associated Gastric Preneoplastic Lesions in Pediatric Patients: A Systematic Review and Meta‐Analysis

作者：Mohammed Awadh Abdun, Lu Xu, Xiao‐Ting Li, Amr Mekky, Maher Al Hussan, Ezaldin M. I. Abuheit, Chen Zhang, Ishtiaq Ur Rahman, Miao Yu, Hafiz Sarwar, Bin‐Bin Yan, Jie-An Xie, Bowei Liu, Songze Ding · 发表于：Helicobacter · 年份：2025 · DOI：10.1111/hel.70021 · 被引用次数：10 · 研究领域：Helicobacter pylori-related gastroenterology studies、Esophageal Cancer Research and Treatment、Gastric Cancer Management and Outcomes

BACKGROUND: Helicobacter pylori (H. pylori) is the major cause of gastric mucosal precancerous lesions in adulthood, but its impact on pediatric patients remains unclear. We aimed to investigate H. pylori-induced gastric precancerous lesions in children and adolescents globally and analyze their influencing factors for related disease management and prevention. MATERIALS AND METHODS: We conducted a comprehensive literature search in major databases to identify studies including pediatric patients with gastric precancerous lesions and H. pylori infection status. Prevalence rates were computed using random-effects or fixed-effect models. A stratified analysis was conducted based on location, age, universal health coverage (UHC), and publication time. RESULTS: Among the 3359 relevant articles screened, 24 studies (7036 participants) met the inclusion criteria. The overall prevalence of precancerous lesions in H. pylori-infected patients was 17.2%, in which atrophic gastritis (AG) and intestinal metaplasia (IM) were 13.5% and 3.6%, respectively. Precancerous lesion rates in infected individuals across different regions were as follows: Africa at 33.8% (AG: 32.6%), Latin America at 22.1% (AG: 17.9%, IM: 4.0%), Asia at 18.1% (AG: 12.4%, IM: 4.4%, Dysplasia: 1.2%), and Europe at 6.3% (AG: 4.3%, IM: 1.7%). Infected adolescents (> 10 years) exhibited a higher prevalence of precancerous lesions than younger children (≤ 10 years) at 14.2% (AG: 9.7%, IM: 2.9%) versus 3.4% (AG: 2.3%, IM: ...