The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease

作者：Rayees Ahmad Naik, Mehak Naseer Mir, Ishfaq Ahmad Malik, Rima Bhardwaj, Fahad M. Alshabrmi, Mahmoud Abdulrahman Mahmoud, Majid Alhomrani, Abdulhakeem S. Alamri, Walaa F. Alsanie, Ahmed Hjazi, Tanmoy Ghatak, Burkhard Pöeggeler, Mahendra Pratap Singh, Gopenath Ts, Sandeep Kumar Singh · 发表于：Frontiers in Bioscience-Landmark · 年份：2025 · DOI：10.31083/fbl25551 · 被引用次数：27 · 研究领域：Alzheimer's disease research and treatments、Cholinesterase and Neurodegenerative Diseases、Medicinal Plants and Neuroprotection

Alzheimer's disease (AD) is the most prevalent cause of dementia and a significant contributor to health issues and mortality among older individuals. This condition involves a progressive deterioration in cognitive function and the onset of dementia. Recent advancements suggest that the development of AD is more intricate than its underlying brain abnormalities alone. In addition, Alzheimer's disease, metabolic syndrome, and oxidative stress are all intricately linked to one another. Increased concentrations of circulating lipids and disturbances in glucose homeostasis contribute to the intensification of lipid oxidation, leading to a gradual depletion of the body's antioxidant defenses. This heightened oxidative metabolism adversely impacts cell integrity, resulting in neuronal damage. Pathways commonly acknowledged as contributors to AD pathogenesis include alterations in synaptic plasticity, disorganization of neurons, and cell death. Abnormal metabolism of some membrane proteins is thought to cause the creation of amyloid (Aβ) oligomers, which are extremely hazardous to neurotransmission pathways, especially those involving acetylcholine. The interaction between Aβ oligomers and these neurotransmitter systems is thought to induce cellular dysfunction, an imbalance in neurotransmitter signaling, and, ultimately, the manifestation of neurological symptoms. Antioxidants have a significant impact on human health since they may improve the aging process by combating free radi...