Association between life’s crucial 9 and severe abdominal aortic calcification in U.S. Adults: the mediating role of the systemic inflammatory response index

作者：Kaifeng Tang, Linping Wang, Jinming Ye, Yuan Feng · 发表于：Frontiers in Endocrinology · 年份：2025 · DOI：10.3389/fendo.2025.1526114 · 被引用次数：6 · 研究领域：Parathyroid Disorders and Treatments、Aortic aneurysm repair treatments、Cardiac Health and Mental Health

Background Life’s Crucial 9 (LC9) is an emerging cardiovascular health scoring system that incorporates Life’s Essential 8 (LE8) alongside mental health factors. However, its relationship with severe abdominal aortic calcification (SAAC) remains poorly understood. Objectives The objective of this study is to investigate the relationship between LC9 scores and the incidence of SAAC in the US population. Methods Data from 2,323 participants were analyzed, originating from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) cycle. In exploring the dynamics of LC9, its constituents, and their relationship with SAAC, we employed advanced statistical methodologies, specifically multivariable logistic regression and weighted quantile sum regression. Subgroup interaction analyses were conducted to reinforce the conclusions, and mediation analysis was employed to investigate how the systemic inflammatory response index (SIRI) influences the connection between LC9 and SAAC. Results In fully adjusted models, an increase of 10 points in LC9 scores was associated with a 26% reduction in the prevalence of SAAC, achieving statistical significance ( P < 0.001). As LC9 scores increased, a significant decline in SAAC prevalence was noted ( P < 0.05). The WQS analysis pinpointed strong links between the occurrence of SAAC and variables including exposure to tobacco, blood pressure levels, blood glucose concentrations, and mental health status, the odds ratio st...