SMARCA4-deficient undifferentiated carcinoma co-existing with primary endometrial gastric (or gastrointestinal) -type carcinoma: a case report

作者：Fan Yang, Haixiao Fu, Xiang Zheng, Yuzhong Yang, Quyan Zhou, Yuanna Liang, Jinhua Zheng, Jing Lin · 发表于：Frontiers in Oncology · 年份：2025 · DOI：10.3389/fonc.2025.1510930 · 被引用次数：2 · 研究领域：Chromatin Remodeling and Cancer、Mechanisms of cancer metastasis、Cancer Mechanisms and Therapy

Dedifferentiated endometrial carcinoma (DEC) is a rare and highly malignant endometrial tumor consisting of both undifferentiated endometrial carcinoma (UEC) and differentiated components (that are typically grade 1 or 2 endometrioid carcinomas). By contrast, the coexistence of UEC with a high-grade endometrial carcinoma has not been well reported. Primary endometrial gastric (gastrointestinal)-type carcinoma (PEGT-carcinoma) is a newly classified and rare type of female genital tract cancer, this neoplasm belongs to high-grade endometrial carcinoma and tends to have a poor outcome. In this study, we reported an atypical case of DEC composed of SMARCA4-deficient UEC and PEGT-carcinoma and reviewed its clinicopathological features.